• ABSTRACT: Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells.  
  Artemisinin becomes cytotoxic in the presence of ferrous iron. Since iron influx is high in cancer cells, artemisinin and its analogs selectively kill cancer cells under conditions that increase intracellular iron concentrations. We report here that after incubation with holotransferrin, which increases the concentration of ferrous iron in cancer cells, dihydroartemisinin, an analog of artemisinin, effectively killed a type of radiation-resistant human breast cancer cell in vitro. The same treatment had considerably less effect on normal human breast cells. Since it is relatively easy to increase the iron content inside cancer cells in vivo, administration of artemisinin-like drugs and intracellular iron-enhancing compounds may be a simple, effective, and economical treatment for cancer. 11/30/2001; Life Sciences

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Web Links

• Selective cancer cell cytotoxicity from exposure to dihydroartemisinin and holotransferrin:  
  Henry Lai, and Narendra P. Singh, Department of Pharmacology, University of Washington Seattle, WA USA
  
• Ancient Chinese folk remedy may hold key to non-toxic cancer treatment
  University of Washington Press Release
  
• Wormwood is the Basis for a Cancer-fighting Pill 
  (Environment News Network)
  
• Georgetown University is seeking a licensee for Use of Artemisinin: 
  Use of ARTEMISININ in the treatment of PAPILLOMA INFECTIONS, CERVICAL DYSPLASIA, AND CERVICAL CANCER
  
• Patent Application - University of Washington: 
  (Methods of inhibition or killing cancer cells using an endoperoxide)
  
• Artesunate, Integrated Safety 
  Rosemary Johann-Liang, M.D. Division of Special Pathogen and Immunological Drug Products
  
• Qinghaosu (ARTEMISININ)
  Artemisinin was originally developed in 1972 in China (Chines Institute of material medicine) from the plant ..................
  
• New Crop FactSHEET - Annual Wormwood
  Purdue University - Center for new crops and plant products
  
• The Cancer Cure Foundation
  Artemesia
  
• Artemisinin - Overview
  Adenoid Cystic Carcinoma Organization International
  
• Chinese Folk Remedy Fights Cancer - Plant compound sparks chain reaction that kills tumor cells
  Articals @ DRELIAZ.COM
  

• ARTEMISININ STUDY ABSTRACTS
  LamMD.Com - An insider's guide to natural medicine.

• Artemisin Structure
  Molecular weight and Chemical names

• Low-toxicity anti-malarial drugs wipe out angiogenesis in lab assays
  Researchers in China have announced that at least two antimalarial drugs, artesunate and dihydroartemisin, suppress angiogenesis in laboratory studies.

• Artemisinin: From Malaria to Cancer Treatment
  By Robert Jay Rowen, MD
  
• Chinese Herb Cures Cancer
  By Dr. Robert Rowen, Second Opinion, Vol.XII, No.5, May 2002.
  
• Neurotoxic Mode of Action of Artemisinin
  Gabriele Schmuck, Elke Roehrdanz, Richard K. Haynes, and Regine Kahl
  
• Alternative Cancer Therapies
  Wellness Directory of Minnesota
  
• Characterization of the First Covalent Adduct between Artemisinin and a Heme Model
  Anne Robert and Bernard Meunier

PDF Files - Download ADOBE ACROBAT READER Here

• Selective toxicity of dihydroartemisinin and holotransferrin toward human breast cancer cells.
  By Narendra P. Singh*, Henry Lai - Life Scineces
  
• Malaria Drug May Hold Key to Nontoxic Treatment.  
  The Breast Cancer Fund Report
  
• Artemisinin in Cancer Treatment 
  Dr. Narendra P. Singh Department of Bioengineering University of Washington Seattle
  
• Assessment of the safety of artemisinin compounds in pregnancy
  Report of two informal consultations convened by World Health Oroganization.
  
• WHO Informal Consultation on clinical neurological investigations required for patients treated with artemisinin compounds and derivatives:
  Report of an Informal Consultation convened by WHO
  
• Inhibition of human cancer cell line growth and human umbilical vein endothelial cell angiogenesis by artemisinin derivatives in vitro
  Huan-Huan Chen *, Hui-Jun Zhou, Xin Fang
  
• Review of Qinghaosu Antimalarial Drug from Traditional Chinese Medicine
  T.T. Hien and N. J. White. Qinghaosu. The Lancet, Vol. 341, pp. 603-608, March 6, 1993.
  
• Herb-based Anti-malaria Drug
  Center of International Dispute - McNeil Jr. DG. New Drug for Malaria Pits U.S. Against Africa. New York Times May 28, 2002.
  

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